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UMR 1060 INSERM

UMR 1060  de Cardiovasculaire, Métabolisme, diabétologie et Nutrition (CarMeN)

carmen.univ-lyon1.fr/

L’UMR INSERM 1060 / Univ-Lyon 1 / INSA-LYON / INRA, dirigée par Hubert Vidal, développe un programme de recherche en cardiologie et physiopathologie de la nutrition associée au diabète et à l’obésité.

Crée en 2011, elle regroupe une partie des forces travaillant dans ce domaine à Lyon associant la recherche cognitive et la recherche clinique. 

   Structurée en 5 équipes complémentaires, l'UMR est adossée à 2 plateformes méthodologiques et expérimentales: le Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA) et l'Institut Multidisciplinaire de Biochimie des Lipides (IMBL).

Une partie de l’Equipe 1 (Adaptations nutritionnelles, environnement et diabètes) est présente au sein de l’IMBL avec une thématique portant sur la taille des adipocytes : fonctions et modélisation)

L’équipe 4 intitulée  INgénierie et FOnction des LIpides et  lipoProtéines (INFOLIP) (responsables Michel Lagarde et Philippe Moulin) est présente principalement à l’IMBL mais aussi partiellement à l’Hôpital Cardiologique de Lyon-Bron. Elle comprend 4 thèmes :

- digestion des lipides et lipopolysaccharides de la flore intestinale

- métabolisme des lipides plasmatiques : génétique des hyperchylomicronémies

- interactions lipoprotéines – cellules sanguines

- métabolisme des acides gras d’intérêt nutritionnel et fonction des métabolites

Dernières publications représentatives :


Naville D, Pinteur C, Vega N, Menade Y, Vigier M, Le Bourdais A, Labaronne E, Debard C, Luquain-Costaz C, Bégeot M, Vidal H, Le Magueresse-Battistoni B. Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice. FASEB J. 2013 Sep;27(9):3860-70.
 
Camont L, Lhomme M, Rached F, Goff WL, Nègre-Salvayre A, Salvayre R, Calzada C, Lagarde M, Chapman MJ, Kontush A. Small, Dense High-Density Lipoprotein-3 Particles Are Enriched in Negatively Charged Phospholipids: Relevance to Cellular Cholesterol Efflux, Antioxidative, Antithrombotic, Anti-Inflammatory, and Antiapoptotic Functionalities. Arterioscler Thromb Vasc Biol. 2013 Oct 3.
 
Plaisancié P, Claustre J, Estienne M, Henry G, Boutrou R, Paquet A, Léonil J. A novel bioactive peptide from yoghurts modulates expression of the gel-forming MUC2 mucin as well as population of goblet cells and Paneth cells along the small intestine. J Nutr Biochem. 2013 Jan;24(1):213-21.
 
Lagarde M, Bernoud-Hubac N, Calzada C, Véricel E, Guichardant M. Lipidomics of essential fatty acids and oxygenated metabolites.Mol Nutr Food Res. 2013 Aug;57(8):1347-58.
 
Luquain-Costaz C, Lefai E, Arnal-Levron M, Markina D, Sakaï S, Euthine V, Makino A, Guichardant M, Yamashita S, Kobayashi T, Lagarde M, Moulin P, Delton-Vandenbroucke I. Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1803-11.
 
Liu M, Chen P, Véricel E, Lelli M, Béguin L, Lagarde M, Guichardant M. Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA. J Lipid Res. 2013 Aug;54(8):2083-94.
 
Lefils-Lacourtablaise J, Socorro M, Géloën A, Daira P, Debard C, Loizon E, Guichardant M, Dominguez Z, Vidal H, Lagarde M, Bernoud-Hubac N. The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism.PLoS One. 2013 May 29;8(5):e63997.
 
Calzada C, Véricel E, Colas R, Guillot N, El Khoury G, Drai J, Sassolas A, Peretti N, Ponsin G, Lagarde M, Moulin P. Inhibitory effects of in vivo oxidized high-density lipoproteins on platelet aggregation: evidence from patients with abetalipoproteinemia.FASEB J. 2013 Jul;27(7):2855-61.
 
Awada M, Meynier A, Soulage CO, Hadji L, Géloën A, Viau M, Ribourg L, Benoit B, Debard C, Guichardant M, Lagarde M, Genot C, Michalski MC. n-3 PUFA added to high-fat diets affect differently adiposity and inflammation when carried by phospholipids or triacylglycerols in mice. Nutr Metab (Lond). 2013 Feb 15;10(1):23.
 
Girard-Egrot A, Lagarde M. Membranes and bioactive lipids. Biochimie. 2013 Jan;95(1):1-2.
 
Lagarde M, Calzada C, Guichardant M, Véricel E.             Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):49-52.
 
Moreno-Navarrete JM, Escoté X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Frühbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernández-Real JM. A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia. 2013 Nov;56(11):2524-2537.
 
Michalski MC, Genot C, Gayet C, Lopez C, Fine F, Joffre F, Vendeuvre JL, Bouvier J, Chardigny JM, Raynal-Ljutovac K; Steering Committee of RMT LISTRAL. Multiscale structures of lipids in foods as parameters affecting fatty acid bioavailability and lipid metabolism. Prog Lipid Res. 2013 Apr 25;52(4):354-373.
 
Vors C, Pineau G, Gabert L, Drai J, Louche-Pélissier C, Defoort C, Lairon D, Désage M, Danthine S, Lambert-Porcheron S, Vidal H, Laville M, Michalski MC. Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial. Am J Clin Nutr. 2013 Jan;97(1):23-36.
 
Guebre-Egziabher F, Alix PM, Koppe L, Pelletier CC, Kalbacher E, Fouque D, Soulage CO. Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function.Biochimie. 2013 Nov;95(11):1971-1979.
 
Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases.Biochimie. 2013 Oct;95(10):1811-27.
 
Soula HA, Julienne H, Soulage CO, Géloën A. Modelling adipocytes size distribution. J Theor Biol. 2013 Sep 7;332:89-95.
 
Pelletier CC, Koppe L, Croze ML, Kalbacher E, Vella RE, Guebre-Egziabher F, Géloën A, Badet L, Fouque D, Soulage CO. White adipose tissue overproduces the lipid-mobilizing factor zinc α2-glycoprotein in chronic kidney disease.Kidney Int. 2013 May;83(5):878-86.
 
Geloen A, Helin L, Geeraert B, Malaud E, Holvoet P, Marguerie G. CD36 inhibitors reduce postprandial hypertriglyceridemia and protect against diabetic dyslipidemia and atherosclerosis. PLoS One. 2012;7(5):e37633.
 
Vors C, Capolino P, Guérin C, Meugnier E, Pesenti S, Chauvin MA, Monteil J, Peretti N, Cansell M, Carrière F, Michalski MC. Coupling in vitro gastrointestinal lipolysis and Caco-2 cell cultures for testing the absorption of different food emulsions. Food Funct. 2012 May;3(5):537-46.
 
Rieusset J, Chauvin MA, Durand A, Bravard A, Laugerette F, Michalski MC, Vidal H. Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance. Biochem Biophys Res Commun. 2012 Jan 6;417(1):439-45.
 
Laugerette F, Furet JP, Debard C, Daira P, Loizon E, Géloën A, Soulage CO, Simonet C, Lefils-Lacourtablaise J, Bernoud-Hubac N, Bodennec J, Peretti N, Vidal H, Michalski MC. Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E374-86.
 
Chapuy-Regaud S, Subra C, Requena M, de Medina P, Amara S, Delton-Vandenbroucke I, Payre B, Cazabat M, Carriere F, Izopet J, Poirot M, Record M. Progesterone and a phospholipase inhibitor increase the endosomal bis(monoacylglycero)phosphate content and block HIV viral particle intercellular transmission. Biochimie. 2013 Sep;95(9):1677-88.
 
Arnal-Levron M, Chen Y, Delton-Vandenbroucke I, Luquain-Costaz C. Bis(monoacylglycero)phosphate reduces oxysterol formation and apoptosis in macrophages exposed to oxidized LDL. Biochem Pharmacol. 2013 Jul 1;86(1):115-21.
 
Désaméricq G, Van Ganse E, Schwalm MS, Bourke A, Moulin P. Severe hypertriglyceridaemia in patients treated with lipid-modifying agents.Diabetes Metab. 2012 Jun;38(3):277-9.
 
Awada M, Soulage CO, Meynier A, Debard C, Plaisancié P, Benoit B, Picard G, Loizon E, Chauvin MA, Estienne M, Peretti N, Guichardant M, Lagarde M, Genot C, Michalski MC. Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells. J Lipid Res. 2012 Oct;53(10):2069-80.
 
Croze ML, Vella RE, Pillon NJ, Soula HA, Hadji L, Guichardant M, Soulage CO. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. J Nutr Biochem. 2013 Feb;24(2):457-66.
 
Hullin-Matsuda F, Tomishige N, Sakai S, Ishitsuka R, Ishii K, Makino A, Greimel P, Abe M, Laviad EL, Lagarde M, Vidal H, Saito T, Osada H, Hanada K, Futerman AH, Kobayashi T. Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.J Biol Chem. 2012 Jul 13;287(29):24397-411.
 
Lagarde M, Bernoud-Hubac N, Guichardant M. Expanding the horizons of lipidomics. Towards fluxolipidomics.Mol Membr Biol. 2012 Nov;29(7):222-8.
 
Volat FE, Pointud JC, Pastel E, Morio B, Sion B, Hamard G, Guichardant M, Colas R, Lefrançois-Martinez AM, Martinez A. Depressed levels of prostaglandin F2α in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity. Diabetes. 2012 Nov;61(11):2796-806.
 
Pillon NJ, Croze ML, Vella RE, Soulère L, Lagarde M, Soulage CO. The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress.Endocrinology. 2012 May;153(5):2099-111.
 
Colas R, Sassolas A, Guichardant M, Cugnet-Anceau C, Moret M, Moulin P, Lagarde M, Calzada C. LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets. Diabetologia. 2011 Nov;54(11):2931-40.
 
Guichardant M, Chen P, Liu M, Calzada C, Colas R, Véricel E, Lagarde M. Functional lipidomics of oxidized products from polyunsaturated fatty acids. Chem Phys Lipids. 2011 Sep;164(6):544-8.

Pillon NJ, Vella RE, Soulere L, Becchi M, Lagarde M, Soulage CO. Structural and functional changes in human insulin induced by the lipid peroxidation byproducts 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal. Chem Res Toxicol. 2011 May 16;24(5):752-62.

Chauveau F, Cho TH, Perez M, Guichardant M, Riou A, Aguettaz P, Picq M, Lagarde M, Berthezène Y, Nighoghossian N, Wiart M. Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. Curr Neurovasc Res. 2011 May;8(2):95-102.

Cohen G, Riahi Y, Shamni O, Guichardant M, Chatgilialoglu C, Ferreri C, Kaiser N, Sasson S. Role of Lipid Peroxidation and PPAR-{delta} in Amplifying Glucose-Stimulated Insulin Secretion. Diabetes. 2011 Nov;60(11):2830-42.

Peyret B, Collardeau S, Touzet S, Loras-Duclaux I, Yantren H, Michalski MC, Chaix J, Restier-Miron L, Bouvier R, Lachaux A, Peretti N. Prevalence of liver complications in children receiving long-term parenteral nutrition. Eur J Clin Nutr. 2011 Jun;65(6):743-9.

Rieusset J, Chauvin MA, Durand A, Bravard A, Laugerette F, Michalski MC, Vidal H. Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance. Biochem Biophys Res Commun. 2011 Dec 7.

Laugerette F, Furet JP, Debard C, Daira P, Loizon E, Geloen A, Soulage CO, Simonet C, Lefils-Lacourtablaise J, Bernoud-Hubac N, Bodennec J, Peretti N, Vidal H, Michalski MC. Oil composition of high fat diet affects differently metabolic inflammation in connection with endotoxin receptors in mice. Am J Physiol Endocrinol Metab. 2011 Nov 15.

Gabert L, Vors C, Louche-Pélissier C, Sauvinet V, Lambert-Porcheron S, Drai J, Laville M, Désage M, Michalski MC. 13C tracer recovery in human stools after digestion of a fat-rich meal labelled with [1,1,1-13C3]tripalmitin and [1,1,1-13C3]triolein. Rapid Commun Mass Spectrom. 2011 Oct 15;25(19):2697-703.

Charrière S, Peretti N, Bernard S, Di Filippo M, Sassolas A, Merlin M, Delay M, Debard C, Lefai E,Lachaux A, Moulin P, Marçais C. GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia. J Clin Endocrinol Metab. 2011 Oct;96(10):E1675-9.
 
Chen P, Véricel E, Lagarde M, Guichardant M. Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. FASEB J. 2011 Jan;25(1):382-8.
 
Davies SS, Bodine C, Matafonova E, Pantazides BG, Bernoud-Hubac N, Harrison FE, Olson SJ, Montine TJ, Amarnath V, Roberts LJ 2nd. Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice. J Alzheimers Dis. 2011;27(1):49-59.

image contact
Hubert Vidal

Service : CarMeN - Cardiovasculaire, Métabolisme, diabétologie et Nutrition
Courriel :
Michel Lagarde

Service : CarMeN - Cardiovasculaire, Métabolisme, diabétologie et Nutrition
Courriel :

UMR 1060
Cardiovasculaire, Métabolisme, diabétologie et Nutrition (CarMeN)

carmen.univ-lyon1.fr/